Membrane Disruption by Very Long Chain Fatty Acids during Necroptosis

Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology

Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found not only as constituents of cellular lipids such as sphingolipids and glycerophospholipids but also as precursors of lipid mediators. Our understanding on the function of VLCFAs is growing in parallel with the identi...

A Role for Very-Long-Chain Fatty Acids in Furrow Ingression during Cytokinesis in Drosophila Spermatocytes

Cell shape and membrane remodeling rely on regulated interactions between the lipid bilayer and cytoskeletal arrays at the cell cortex. During cytokinesis, animal cells build an actomyosin ring anchored to the plasma membrane at the equatorial cortex. Ring constriction coupled to plasma-membrane ingression separates the two daughter cells. Plasma-membrane lipids influence membrane biophysical p...

Inhibition of Thermophilic Anaerobic Digestion of Waste Food by Long Chain Fatty Acids and Propionate

Very-long-chain fatty acids are required for cell plate formation during cytokinesis in Arabidopsis thaliana.

Acyl chain length is thought to be crucial for biophysical properties of the membrane, in particular during cell division, when active vesicular fusion is necessary. In higher plants, the process of cytokinesis is unique, because the separation of the two daughter cells is carried out by de novo vesicular fusion to generate a laterally expanding cell plate. In Arabidopsis thaliana, very-long-ch...

Biosynthesis of very long chain fatty acids by the sciatic nerve of the rabbit.

The alkanes, a new class of neurolipids, are accumulated in the brain myelin when compared to the other brain subfractions [l--4]. The role of these hydrophobic substances in the myelin formation is far from clear. It appears that alkanes are required for a correct myelination, since the remaining myelin of the Quaking mutant, which bears a defect of myelin formation, presents only 30%total alk...